Cambridge Encyclopedia :: Cambridge Encyclopedia Vol. 29

George E(mil) Palade - Biography

Cell biologist, born in Iasi, NE Romania. He trained as a doctor in Bucharest, and was professor of anatomy there until he moved to the USA in 1946, where he became a US citizen in 1952. He worked under Albert Claude at the Rockefeller Institute, New York City (1946–72), and from 1972 headed cell biology at Yale Medical School. His work on the fine structure of cells as revealed by electron microscopy led him in 1956 to discover the small organelles within cells, called ribosomes, in which RNA synthesizes protein. He shared the 1974 Nobel Prize for Physiology or Medicine.

George Emil Palade (b. In 1974, he shared with two colleagues the Nobel Prize in Physiology or Medicine for discoveries concerning the structure and function of organelles in biological cells.

Biography

George Palade received a M.D.

In 1952, Palade became a naturalized citizen of the United States. He was a professor at the Rockefeller Institute (1958-1973), Yale University Medical School (1973-1990), and University of California, San Diego (1990-present).

Alongside the Nobel Prize, he received the National Medal of Science in 1986.

At the Rockefeller Institute, Palade used electron microscopy to study the internal organization of such cell structures as mitochondria, chloroplasts, the Golgi apparatus, and others.

His name has become attached to the Weibel-Palade bodies (a storage organelle unique to the endothelium, containing von Willebrand factor and various proteins) which he described together with the Swiss anatomist Ewald R.

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